Voskoboinik Alexei Yuriyovych

Position

Professor of the Department of Composite Materials, Chemistry and Technologies

Academic degree

doctor of pharmaceutical sciences

Academic title

professor at the department “Composite materials, chemistry and technologies”, certificate – AP No. 006143

Education

2004 Zaporizhzhia State Medical University, specialty “Pharmacy”, Master of Pharmacy; 2006. Zaporizhzhia National University, specialty “Management of foreign economic activity”, specialist with qualification “economist-manager”. Vosokoboynik O.Yu. is a highly qualified specialist in the chemistry of organic compounds, including those relevant to the chemistry and technology of polymeric materials.

Subjects taught

Chemistry and basics of ecology Physico-chemistry of polymer materials and composite materials Polymer composite materials Chemical technologies for the production of high molecular weight compounds and polymer nanocomposites Organic compounds in industry

Main languages ​​of communication

Ukrainian (fluent), English (level B2 in accordance with the All-European recommendations on language education, ESOL International Pearson Edexcel certificate #PQS2021921326769)

Participation in the work of councils and state structures:

  • Member of the Academic Council of the Faculty of Construction, Architecture and Design of Zaporizhzhia Polytechnic National University;

  • Member of the working group on the preparation of proposals for the conclusions of the best available technologies and management methods for surface treatment with organic solvents, including chemical protection of wood and wood products at the Ministry of Environmental Protection and Natural Resources (2024);

  • Member of the group of Ukrainian experts of the Ministry of Education and Science of Ukraine for conducting scientific and scientific and technical examination of objects of examination in the field of scientific and scientific and technical activity according to the scientific directions in which the examination will be carried out;

  • Member of the editorial board of the "Achievements of Clinical and Experimental Medicine" publication.

Theses:

  • Candidate's thesis on the specialty 15.00.02 "Pharmaceutical chemistry and pharmacognosy" on the topic "Synthesis, transformation, physico-chemical and biological properties of [{2-R-(3H)-quinazolin-4-ylidene}hydrazono]carboxylic acids", defended in the specialized academic council of the Lviv National Medical University named after Danylo Halytskyi. The year of protection is 2008.

  • Doctoral dissertation on the specialty 15.00.02 "Pharmaceutical chemistry and pharmacognosy" on the topic "[1,2,4,]Triazino[c]quinazolines: synthesis, transformation, physico-chemical and biological properties", defended in the specialized academic council of the Zaporizhia State Medical University. The year of protection is 2019.

Scientific interests:

  • Medicinal chemistry

  • Organic chemistry

  • Corrosion and corrosion protection

  • Implementation of innovative technologies in the teaching of chemical disciplines

Total scientific works: 210 scientific works, including 105 scientific articles (including 54 published in publications indexed by Scopus and Web of Science bibliographic databases), 87 abstracts of reports at scientific meetings, 11 patents of Ukraine for inventions, 6 patents of Ukraine for utility models, 1 chapter in a collective monograph.

Main scientific works (publications):

  • Synthesis and biological activity of novel N-cycloalkyl-(cycloalkylaryl)-2-[(3-R-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazoline-6-yl)thio]acetamides / Berest G. G., Voskoboynik A. Yu., Kovalenko S. I., Antypenko A. M., Nosulenko I. S., Katsev A. M., Shandrovskaya A. S. European Journal of Medicinal Chemistry. 2011. No. 46. P. 6066-6074. (Quartile 1 according to Scimago).

  • Hydrazinolysis of 3 R [1,2,4]Triazino[2,3-c]quinazolin-2-ones. Synthetic and Theoretical Aspects / Sergeieva T. Yu., Voskoboynik O. Yu., Okovytyy S. I., Kovalenko S. I., Shishkina Sv. V., Shishkin O. V., Leszczynski J. J. Phys. Chem. A. 2014. No. 118. P. 1895-1905. (Quartile 1 according to Scimago).

  • Synthesis and antimicrobial activity of 6-thioxo-6,7-dihydro-2H-[1,2,4]triazino¬[2,3-c]quinazolin-2-ones derivatives / Nosulenko I. S., Voskoboynik O. Yu., Berest G. G., Safronyuk S. L., Kovalenko S. I., Kamyshnyi O. M., Polishchuk N. M., Sinyak R. S., Katsev A. V. Sci. Pharm. 2014. No. 82. P. 483-500 (Quartile 2 according to Scimago).

  • Novel N-aryl(alkaryl)-2-[(3-R-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazoline-6-yl)thio]acetamides: synthesis, cytotoxicity, anticancer activity, compare analysis and docking / Kovalenko S. I., Nosulenko I. S., Voskoboynik A. Yu., Berest G. G., Antypenko L. M., Antypenko A. N., Katsev A.M. Medicinal Chemistry Research. 2013. No. 22. P. 2610-2632. (Quartile 2 according to Scimago).

  • N-R-2-[(3-R-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazoline-6-yl)thio]acet-amides with thiazole and thiadiazole fragments in a molecules. Synthesis, physico-chemical properties, cytotoxicity research by bioluminescence inhibition, anticancer activity / Kovalenko S. I., Nosulenko I. S., Voskoboynik A. Yu., Berest G. G., Antypenko L. M., Antypenko A. N., Katsev A. M. Sci. Pharm. 2012. No. 80. P. 837-865. (Quartile 2 according to Scimago).

  • Synthesis of new 6-{[(dialkylamino(heterocyclyl)alkyl]thio}-3-R-2H-[1,2,4]triazino[2,3-c]quinazoline-2-ones and evaluation of their anticancer and antimicrobial activities / Berest G. G., Voskoboynik O. Yu., Kovalenko S. I., Nosulenko I. S., Antypenko L. M., Antypenko O. M., Shvets V. M., Katsev A. M. Pharm. 2012. P. 37-65 (Quartile 2 according to Scimago).

  • Thio-containing pteridines: Synthesis, modification, and biological activity / Kazunin, M.S., Groma, N.V., Nosulenko, I.S., ...Voskoboinik, O.Y., Kovalenko, S.I. Archiv der Pharmazie, 2022. (Quartile 2 according to Scimago).

  • 5+1-Heterocyclization as preparative approach for carboxy-containing triazolo[1,5-c]quinazolines with anti-inflammatory activity / Krasovska N., Berest G., Belenichev I., Severina H., Nosulenko I., Voskoboinik O., Okovytyy S, Kovalenko S., European Journal of Medicinal Chemistry, 2024, Volume 266, 116137 (Quarter 1 according to Scimago).

The most recent publications - for the last 2 years:

  • Nosulenko I.S., Kazunin M.S., Kinichenko A.O., Antypenko O.M., Zhurakhivska L.R., Voskoboinik O.Yu., Kovalenko S.I. Dihydrofolate reductase inhibitors among pteridine and furo[3,2-g] pteridine derivatives (2021) Biopolymers and Cell, 37 (2), pp. 143 - 152, DOI: 10.7124/bc.000A51

  • Krasovska N., Berest G., Belenichev I., Severina H., Nosulenko I., Voskoboinik O., Okovytyy S., Kovalenko S. 5+1-Heterocyclization as preparative approach for carboxy-containing triazolo[1,5-c]quinazolines with anti-inflammatory activity European Journal of Medicinal Chemistry, 2024, Volume 266, 116137, doi:10.1016/j.ejmech.2024.116137.

  • Effects of the Aronia melanocarpa extract action on the activity of mitochondrial creatine kinase under immobilization stress in old rats. Shvets V., Maslak H., Davydov V., Berest H. Nosulenko I., Voskoboinik O., Omelianchyk L., Brazhko O. Hacettepe University Journal of the Faculty of Pharmacy, 2023, Volume 43, Issue 4, 333-339, doi:10.52794/hujpharm.1269999.

  • Reactions of 1,4-NCCN-, 1,4-NNCN- and 1,5-NCCCN-binucleophiles with dicarboxylic acids cyclic anhydrides as a method of heterocyclic compounds synthesis (a review). Skoryna D.Yu., Voskoboinik O., Kovalenko S.I. Voprosy Khimii i Khimicheskoi Tekhnologii, 2023, Volume 3, Pages 29 - 53, doi:10.32434/0321-4095-2023-148-3-29-53.

  • Methods of synthesis of quinazolines and their condensed analogues – potential anti-inflammatory agents (review). Krasovska N., Koptieva S., Posudiievska O., Kyrylakha S., Voskoboinik O., Okovytyy S., Kovalenko S. Journal of Chemistry and Technologies, 2023, Volume 31, Issue 2, Pages 385 – 410, doi:10.15421/jchemtech.v31i2.280199.

  • Search for new tyrosine kinase inhibitors among 2-(3-R-1H-1,2,4-triazol-5-yl)anilines as potential antitumor agents using molecular docking. Pylypenko O., Voskoboinik O., Sviatenko L., Kovalenko S., Okovytyy S. ScopusJournal of Chemistry and Technologies, 2023, Volume 31, Issue 2, Pages 419 – 429, doi:10.15421/jchemtech.v31i2.284813.

  • In silico and in vivo screening of triamterene synthetic analogues as promising diuretics. Sokolova K.V., Stavytskyi V.V., Voskoboinik O.Yu., Podpletnya O.A., Kovalenko S.I. Medical perspectives, 28(3): 4-15.

Advanced training:

  • 2012 - advanced training "Modern aspects of higher education pedagogy at the stage of reforming the medical field", Zaporizhia State Medical University, Zaporizhia National University;

  • 2016 – thematic improvement courses "Technology of developing online courses on the EDX distance learning platform", Zaporizhzhia State Medical University (78 hours);

  • 2017 - advanced training "Current issues of pedagogy and psychology in higher education", Zaporizhia State Medical University, Zaporizhia National University;

  • 2020 - the program of innovator educators of Microsoft Corporation "Organization of distance learning based on MS Teams cloud services."

International internship:

  • 2019 - internship at the Neubrandenburg University of Applied Sciences (Hochschule Neubrandenbur), Germany.

  • 2023 - international scientific and pedagogical internship within the VI international scientific congress "Society of Ambient Intelligence 2023", 6 credits, 180 hours (certificate ID 343-2023).

Non-formal education:

  • Virtual online workshop "Advanced and Modern NMR Techniques" Held on November 7-9, 2020 at the Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.

  • II European Chemistry School for Ukrainians (held from 22 May to 22 July 2025, 180 ECTS credits.

Participation in project and grant activities:

  • responsible executor of the NDR financed by the Ministry of Health from the state budget of Ukraine on the topic: "Directed search for biologically active compounds among substituted triazinoquinazolines and creation of drug candidates based on them", state no. registration number 0114U000968, execution period 2014-2016;

  • responsible executor of the NDR financed by the Ministry of Health from the state budget of Ukraine on the topic: "Directed search for anti-inflammatory agents among condensed and spiro-condensed derivatives of quinazoline" state no. registration number 0118U004370, implementation period 2018-2020;

  • the responsible executor of the NDR, financed by the Ministry of Health from the state budget of Ukraine on the topic: "Design and synthesis of condensed pyrimidines and the creation of potential medicinal products based on them with anti-inflammatory, neuro- and metabolitotropic effects" state no. registration number 0122U000584, due in 2022.

Textbooks, training aids:

  • Antimalarial drugs. Quinine and its analogues by pharmacological action. Study guide for students of pharmaceutical faculties specializing in "Pharmacy". SI. Kovalenko, O.V. Kryvoshey, O.Yu. Voskoboynik, H.G. Berest, A.K. White, 324 pages, recommended by the Center for Higher Medical Education of the Ministry of Health of Ukraine.

  • Perfumery and cosmetic products. Study guide for students of the pharmaceutical faculties of the "TPKZ" specialty. SI. Kovalenko, L.I. Kucherenko, A.F. Vlasenko, L.G. Cherkovska, O.V. Kryvoshey, O.Yu. Voskoboynik, G.I. Tkachenko, A.K. White, 316 pages, recommended by the Center for Higher Medical Education of the Ministry of Health of Ukraine.

Publications and speeches at scientific conferences:

  • Investigation of the reaction mechanism of the interaction of 6-R-3-(2-aminophenyl)-1,2,4-triazin-5-ones with electrophilic reagents using quantum chemical calculations Sergeeva T.Yu., Voskoboynik O.Yu., Okovity S.I., Kovalenko S.I. XXIII Ukrainian Conference on Organic Chemistry (September 16-20, 2013). – Chernivtsi, 2013. – P. 162.

  • [1,2,4]Triazino[2,3-c]quinazolines: synthesis, transformations and biological activity. Voskoboinik O.Y., Kovalenko S.I. Chemistry of Nitrogen Containing Heterocecles, CNCH-2015 : Book of abstracts, November 9-13, 2015. Kharkiv, 2015. O-24.

  • Complex quantum-chemical and spectral study of tautomeric properties of some heterocyclic compounds, S. I. Okovyty, T. Yu. Sergeeva, S. V. Kholodnyak, O. Yu. Voskoboynik, S. I. Kovalenko, XXIV Ukrainian Conference on Organic Chemistry, September 19-23. 2016. Poltava, 2016. P. 20.

  • 3-(2-Aminophenyl)-6-R-1,2,4-triazin-5(2H)-ones in reaction with aryliso(thio)cyanates Voskoboynik O. Yu., Kovalenko S. I., 8th International Conference “Chemistry of nitrogen containing heterocycles” in memoriam of Prof. Valeriy Orlov (November 12-16, 2018). - Kharkiv, 2018. - P. 152.

  • 2-Azaheterylanilines in the synthesis of polycondensed quinazoline derivatives V.V. Stavytskyi, O.M. Antipenko, K.P. Shabelnyk, O.Yu. Voskoboynik, S.I. Kovalenko. Mate. Jubilee XXV Ukrainian Conference on Organic and Bioorganic Chemistry, dedicated to the 80th anniversary of the IOC of the National Academy of Sciences of Ukraine and the 30th anniversary of the IBONH named after V.P. Chef of the National Academy of Sciences of Ukraine (September 16-20, 2019). – Lutsk: East European National University named after Lesi Ukrainka, 2019. - P. 77.

  • Purposeful search of novel anti-inflammatory agents among substituted pyrrolo[1,2-a][1,2,4]azolo-(azino-)[c]quinazolines. V. Stavytskyi, N. Krasovska, O. Voskoboinik, S. Kovalenko. 10th International Pharmaceutical Conference "Science and Practice 2019" Kaunas (Lithuania) 11/15/2019.

  • Voskoboynik O.Yu., Demyanenko V.V. Justification of the possibility of using 3-R-2Hbenzo[e][1,2,4]triazino[2,3-c][1,2,3]triazin-2-ones as polymerization initiators. Abstracts of reports of the scientific and technical conference "Science Week-2023. Faculty of Construction, Architecture and Design", Zaporizhzhia, April 24-28, 2023 NU "Zaporizhia Polytechnic", 2023

  • Design and search of promising diuretics in a series of 6-R1-7-R2-2-oxo-(imino-, thioxo-, hydrazono-)-2,3-dihydropteridin-4(1H)-ones and their functional derivatives. Sokolova K.V. , Podpletnya O.A. , Berest H.G. , Voskoboynik O.Yu., Kovalenko S.I. Chemical and biopharmaceutical technologies: collection of scientific papers / by general ed. V. Bessarabov, V. Lubenets. Tallinn: Nordic Sci Publisher, 2023. 392 p. ISBN 978-9916-4-2232-8 p. 120-123.

  • Hepatoprotective activity and toxicity of novel pteridine derivatives N. Groma, O. Voskoboinik, V. Shvets Mechanisms of the development of pathological processes and diseases and their pharmacological correction: materials VI science-practice. Internet Conf. from international participation, November 16 2023, Kharkiv. - Kharkiv: NFaU, 2023. - P. 43.

  • Synthesis and biological activity of ([1,2,4]triazolo[1,5-c]quinazolin-2-yl)-benzoic acids N. I. Krasovska, G. G. Berest, O. Yu. Voskoboynik, S. I. Kovalenko Mat. conf. Materials of the International Internet Conference "Modern chemistry of medicines", May 18, 2023, p. 178-179.

  • Sinyavskyi S. V., Voskoboynik O. Yu., Kopteva S. D, Kovalenko S. I. Benzo[e]azolo-(azino-)[c][1,2,3]triazines: synthesis methods and application prospects VII International (XVII Ukrainian) Scientific conference for students and young scientists “Current chemical problems - 2024” Abstract book. ISSN (print/on-line) 2708-0536/2708-0544, c. 93

  • Bershak A.Yu., Voskoboynik O.Yu., Kopteva S.D., , Kovalenko S.I. New condensed benzo[e][1,4]diazepine derivatives with triazole and triazine fragments VII International (XVII Ukrainian) Scientific conference for students and young scientists “Current chemical problems - 2024” Abstract book. ISSN (print/on-line) 2708-0536/2708-0544, c. 73

  • Karpenko, O.V. Heterocyclic ensembles based on substituted 4-hydrazinoquinazolines. / O.V. Karpenko, O.Yu. Voskoboynik S.I. Kovalenko // Proceedings of the XXVI Ukrainian Conference on Organic and Bioorganic Chemistry. Uzhgorod, September 16-20, 2024 / Uzhgorod National University. Uzhhorod, 2024. Z-21

  • Hrytsak, O.A. 6-(Chloro(R2)methyl)-3-R1-2H-[1,2,4]triazino[2,3-c]quinazolin-2-ones in the synthesis of biologically active compounds. / O.A. Hrytsak, K.P. Shabelnyk, O.Yu. Voskoboynik, S.I. Kovalenko // Proceedings of the XXVI Ukrainian Conference on Organic and Bioorganic Chemistry. Uzhgorod, September 16-20, 2024 / Uzhgorod National University. Uzhhorod, 2024. Z-21

  • Voskoboynik, O.Yu. Anti-corrosion coating for steels based on epoxy resins filled with heterocyclic antioxidants [Electronic resource] / O.Yu. Voskoboynik, O.O. Mandych // Science Week-2024. Faculty of Construction, Architecture and Design. Abstracts of reports of the scientific and practical conference, Zaporizhzhia, April 15–19, 2024. [Electronic resource] / Redcol. : Vadim SHALOMYEV (corresponding editor) Electron. data. – Zaporizhzhia: Zaporizhzhya Polytechnic University, 2024. – P. 128–129.

Membership in professional organizations and/or public associations:

  • Academician of the Academy of Sciences of the Higher School of Ukraine

  • Member of the NGO "All-Ukrainian Pharmaceutical Chamber"

Year of commencement of activities at the university: from 02/16/2023.

Contacts

Address:

69063, Ukraine, Zaporizhzhia, str. 64 University Street, main building

Classroom:

377

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